陈昌亚，研究员，博士研究生导师。获得国家自然科学基金优秀青年科学基金项目（海外）、人社部高层次留学人才回国资助等项目资助。院校引进人才，2024年加入院校。曾于2018年在费城儿童医院从事博士后研究工作，于2023年任研究科学家。

课题组致力于整合单细胞多组学和生物信息学，研究血液系统疾病的发病机制和耐药机制。在泛白血病视野下，构建了覆盖急性髓系、B/T急性淋巴及混合表型白血病的单细胞多组学图谱，系统揭示了耐药相关白血病干细胞的分子特征及治疗靶点。课题组建立了急性白血病干细胞样细胞的多组学图谱，为高危白血病的风险分层与靶向治疗提供了理论基础与临床转化方向。共发表SCI论文25篇，H指数17，Google Scholar总被引3200余次。

1. Chen C#, Xu J#, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding Y, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang J, Bernt KM, Teachey DT*, Tan K*. Single-cell pan-leukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood (2025) 145 (23): 2685–2700.

2. Xu J#,  Chen C#, Vincent T, Pölönen P, Elsayed A, Hu J, Yoshimura S, Yu W, Chen CH, Li E, Shraim R, Newman H, Chen G, Ding Y, Thadi A, Ahn K, Bandyopadhyay S, Peng J, Sun Y, Frank D, Loh M, Raetz E, Chen Z, Wood B, Devidas M, Dunsmore KP, Winter SS, Wu G, Pounds SB, Hunger SP, Bernt K, Yang J, Mullighan CG, Tan K*, Teachey D*. A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. 2024. Nature Cancer. https://doi.org/10.1038/s43018-024-00863-5

3. Chen C#, Yu W#, Alikarami F#, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding Y, Hunger SP, Wu H, Brown P, Guest E, Barrett D*, Bernt K*, Tan K*. Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. (2022) 139(14): 2198-2211.

4. Chen GM#, Chen C#, Das RK#, Gao P, Chen CH, Ding Y, Uzun Y, Yu W, Zhu Q, Grupp SA, Barrett D*, Kai Tan*. Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy. 2021. Cancer Discovery. 11(9), 2186-2199 (C100)

5. Chen C#, Yu W#, Yang H, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, and Tan K*. Spatial genome re-organization between fetal and adult hematopoietic stem cells. 2019. Cell Reports. 29(12), 4200-4211. e7

6. Gao P#, Chen C#, Howell ED#, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann A, Speck NA*, and Tan K*. Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. 2020. Genes & Development. 2020/6/4

7. Cao Z#, Chen C#, He B, Tan K* and Lu C*. A microfluidic device for epigenomic profiling using 100 cells. 2015. Nature Methods. Oct;12(10):959-62