叶子璐，研究员，博士生导师。2007 年考入华中科技大学生物技术专业。2011年在中国科学院生物物理研究所攻读硕士学位。丹麦哥本哈根大学细胞与遗传医学博士。长期致力于基于质谱的前沿蛋白质组学技术研究。曾获得国家自然科学基金优秀青年科学基金项目(海外)的资助。院校引进人才，2023年加入院校。曾担任人类蛋白质组组织(HUPO)生物与疾病人类蛋白质组计划(B/D-HPP)委员会委员、中国生物化学与分子生物学会蛋白质组学专业分会副秘书长。

长期从事基于质谱技术的蛋白质组学与糖组学方法学创新及多维组学研究，在单细胞及痕量蛋白质组学、高通量定量分析和糖基化研究等方向取得系列原创性成果。近年来，团队开发了Chip-Tip和One-Tip等高灵敏度、高通量单细胞蛋白质组学方法，以及Glyco-DIA等糖蛋白质组学技术，显著提升了检测深度和精确性。研究成果发表SCI论文30余篇，其中以第一作者或通讯作者发表13篇，发表于Cell、Nature Methods（x2）、Nature Biotechnology、Nature Communications等国际著名期刊。

1.Sabatier P, Lechner M, Guzmán UH, Beusch CM, Zeng X, Wang L, Izaguirre F, Seth A, Gritsenko O, Rodin S, Grinnemo KH, Ye Z#, Olsen JV#. Global analysis of protein turnover dynamics in single cells. Cell. 2025. 188(9):2433. (IF = 42.5)

2.Ye Z#*, Sabatier P#, van der Hoeven L, Lechner MY, Phlairaharn T, Guzman UH, Liu Z, Huang H, Huang M, Li X, Hartlmayr D, Izaguirre F, Seth A, Joshi HJ, Rodin S, Grinnemo KH, Hørning OB, Bekker-Jensen DB, Bache N, Olsen JV*. Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics. Nature Methods, 2025: 1-11. (IF = 32.1)

3.Guzman UH#, Martinez-Val A#, Ye Z#, Damoc E, Arrey TN, Pashkova A, Renuse S, Denisov E, Petzoldt J, Peterson AC, Harking F, Østergaard O, Rydbirk R, Aznar S, Stewart H, Xuan Y, Hermanson D, Horning S, Hock C, Makarov A, Zabrouskov V, Olsen JV*. Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition. Nature Biotechnology 2024,1-12. (IF = 41.7)

4.Ye Z#*, Sabatier P#, Martin-Gonzalez J, Eguchi A, Lechner M, Østergaard O, Xie J, Guo Y, Schultz L, Truffer R, Bekker-Jensen DB, Bache N, Olsen JV*. One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes. Nature Communications 2024, 15(1): 2474. (IF = 15.7，ESI)

5.Ye Z#, Kilic G#, Dabelsteen S#, Marinova IN, Thøfner JFB, Levann AMR, Bagdonaite I, Vakhrushev S, Brakebusch CH, Olsen J* and Wandall H*. Loss of TGF-βRII signaling induces invasive tissue growth in a human organotypic skin model. Science Signaling 2022, 15(761). (IF = 7.3)

6.Ye Z#, Batth T, Rüther PL and Olsen J. A deeper look at carrier proteome effects for single-cell proteomics. (2022) Communications Biology, 10.1038/s42003-022-03095-4 (IF = 6.55)

7.Mao Y, Wang S, Zhao Y, Konstantinidi A, Sun L, Ye Z* and Vakhrushev SY*. Systematic Evaluation of Fragmentation Methods for Unlabeled and Isobaric Mass Tag-Labeled O-Glycopeptides. (2021) Anal Chem 93:11167-11175. (IF =8.01)

8.Ye Z# and Vakhrushev SY. The Role of Data-Independent Acquisition for Glycoproteomics. (2021) Mol Cell Proteomics 20:100042. (IF = 5.91)

9.Ye Z#, Mao Y, Clausen H and Vakhrushev SY. Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries. (2019) Nat Methods 16:902-910. (IF = 30.82)

10.Zhang C#, Ye Z#, Xue P, Shu Q, Zhou Y, Ji Y, Fu Y, Wang J and Yang F. Evaluation of Different N-Glycopeptide Enrichment Methods for N-Glycosylation Sites Mapping in Mouse Brain. (2016) J Proteome Res 15:2960-8. (IF = 4.27)